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. 2015 May 22;8(4):298–304. doi: 10.1111/cts.12275

Figure 4.

Figure 4

Sodium channel blocker prilocaine decrease DMPK protein in vivo. CD‐1 wild‐type mice were treated with daily IP injections of all three sodium channel blockers for 5 days. Control mice were treated with equal volume of vehicle. Gastrocnemius muscle was harvested for Western blot analysis. Representative Western blot (A) and densitometric quantification of DMPK protein (B and C) relative to tubulin upon treatment with mexiletine (25 mg/kg). Representative Western blot (D) and densitometric quantification of DMPK protein (E and F) relative to tubulin upon treatment with prilocaine (1.25 mg/kg). Representative Western blot (G) and densitometric quantification of DMPK protein (H and I) relative to tubulin upon treatment with procainamide (25 mg/kg). Three mice per treatment group (control and treatment) were used. Mean ± SEM (bars) is shown. All lanes were run on the same gel but were noncontiguous. *p < 0.05; **p < 0.01; t‐test.