Table 4.

Critical appraisal of RCT using Cochrane Collaboration guidelines

	A	B	C	D	E	F
Study	Adequate sequence generation	Adequate allocation concealment	Adequate blinding	Incomplete outcome data addressed	Free of selective reporting	Free of other bias
Faes 2011 [29]	+	−	+	−	+	+

A - Did the allocation sequence involve a random component or minimization?

B - Was allocation adequately concealed, e.g., through central allocation?

C - Were participants and key study personnel reliably blinded and/or it was unlikely that outcome measurement would be influenced by lack of blinding?

D - Was incomplete outcome data adequately addressed?

E - Are reports of the study free of suggestions of selective reporting, e.g., the protocol is available and all outcomes were reported in a prespecified way?

F - Was the study apparently free of other problems that could put it at a risk of bias?