Table 1.
Characteristics of 509 included studies
| For-profit (n = 148) | Mixed profit and nonprofit (n = 117) | Nonprofit (n = 244) | |
|---|---|---|---|
| Medical journal, n (%) | |||
| JAMA | 17 (11%) | 37 (32%)a | 63 (26%)a |
| The Lancet | 45 (30%) | 33 (28%) | 91 (37%) |
| New England Journal of Medicine | 86 (58%) | 47 (40%)a | 90 (37%)a |
| Sample size | |||
| Median | 800 | 637 | 647 |
| Intervention type, n (%) | |||
| Drug | 118 (80%) | 65 (56%)a | 93 (38%)a,b |
| Device | 18 (12%) | 6 (5%) | 16 (7%) |
| Procedure | 4 (3%) | 7 (6%) | 42 (17%)a,b |
| Procedure and/or device/drug/behavior | 5 (3%) | 21 (18%)a | 21 (9%)b |
| Behavior | 0 (0%) | 1 (1%) | 45 (18%)a,b |
| Other | 3 (2%) | 17 (15%)a | 27 (11%)a |
| Endpoint, n (%) | |||
| Clinical | 110 (74%) | 91 (78%) | 196 (80%) |
| Surrogate | 38 (26%) | 26 (22%) | 48 (20%) |
aDenotes statistical significant difference compared with the for-profit-funded group (p < 0.05)
bDenotes statistical significant difference compared with mixed group funded research (p < 0.05)