Table 4.

Multivariate metaregression examining factors associated with effect size

Factor	Exponentiated coefficient, OR (95% CI)	p Value
Medical journal
The Lancet	Reference
JAMA	−0.21 (−0.17, 0.12)	0.77
New England Journal of Medicine	0.024 (−0.10, 0.15)	0.70
Sample size
Mean	0 (0, 0)	0.76
Intervention type
Drug	Reference
Device	−0.21 (−0.40, −0.01)	0.04
Procedure	0.04 (−0.15, 0.23)	0.67
Procedure and/or device/drug	−0.20 (−0.40, −0.00)	0.049
Behavior	0.02 (−0.19, 0.23)	0.85
Other	−0.18 (−0.35, 0.00)	0.053
Endpoint
Clinical	Reference
Surrogate	0.38 (0.25, 0.51)	<0.001
Funding source
Profit	Reference
Mixed	−0.22 (−0.37, 0.07)	0.005
Nonprofit	−0.28 (−0.42, −0.15)	<0.001