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IL-17/IL-17R downregulate apoptosis by inducing autophagy. 3-MA (10 mM) and AG490 (15 µg/ml) were added to the culture medium for 1 h prior to Oxa treatment, after which SMMC-7721 cells were treated with 20 µg/ml Oxa for 18 h. BCL-2 and BAX protein expression was determined by western blot analysis. GAPDH was used as an internal control. Oxa, oxaliplatin; IL-17, interleukin-17; IL-17R, IL-17 receptor; BCL-2, B-cell lymphoma-2; BAX, BCL-2-associated X protein; 3-MA, 3-methyladenine.
