Table 5.
Relationships between clinicopathological characteristics and pathological response evaluated by China-TRG system
| Characteristics | Total cases (n = 192), no. (%) | China-TRG | P value | ||
|---|---|---|---|---|---|
| Severe response (n = 34), no. (%) | Moderate response (n = 57), no. (%) | Mild response (n = 101), no. (%) | |||
| Gender | 0.063 | ||||
| Male | 139 (72.4) | 30 (21.6) | 41 (29.5) | 68 (48.9) | |
| Female | 53 (27.6) | 4 (7.5) | 16 (30.2) | 33 (62.3) | |
| Age | 0.820 | ||||
| < 55y | 89 (46.4) | 15 (16.9) | 25 (28.1) | 49 (55.1) | |
| ≥ 55y | 103 (53.6) | 19 (18.4) | 32 (31.1) | 52 (50.5) | |
| Location | 0.906 | ||||
| Esophagogastric junction | 44 (22.9) | 6 (13.6) | 14 (31.8) | 24 (54.5) | |
| Proximal gastric | 71 (37) | 14 (19.7) | 22 (31) | 35 (49.3) | |
| Distal gastric | 77 (40.1) | 14 (18.2) | 21 (27.3) | 42 (54.5) | |
| Maximal diameter of tumor bed | <0.001 | ||||
| < 4.5 cm | 108 (56.2) | 28 (25.9) | 32 (29.6) | 48 (44.4) | |
| 4.5–8 cm | 64 (33.3) | 5 (7.8) | 21 (32.8) | 38 (59.4) | |
| > 8 cm | 20 (10.4) | 1 (5) | 4 (20) | 15 (75) | |
| Histological differentiation | 0.001 | ||||
| Well-moderate | 45 (23.4) | 16 (35.6) | 12 (26.7) | 17 (37.8) | |
| Poor | 147 (76.6) | 18 (12.2) | 45 (30.6) | 84 (57.1) | |
| Laurén classification | 0.264 | ||||
| Intestinal | 77 (40.1) | 18 (23.4) | 22 (28.6) | 37 (48.1) | |
| Diffuse | 73 (38) | 13 (17.8) | 20 (27.4) | 40 (54.8) | |
| Mixed | 42 (21.9) | 3 (7.1) | 15 (35.7) | 24 (57.1) | |
| LVI | <0.001 | ||||
| Negative | 94 (49) | 30 (31.9) | 35 (37.2) | 29 (30.9) | |
| Positive | 98 (51) | 4 (4.1) | 22 (22.4) | 72 (73.5) | |
| PNI | <0.001 | ||||
| Negative | 76 (39.6) | 33 (43.4) | 20 (26.3) | 23 (30.3) | |
| Positive | 116 (60.4) | 1 (0.9) | 37 (31.9) | 78 (67.2) | |
| AJCC ypT category | <0.001 | ||||
| 0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | |
| 1 | 20 (10.4) | 12 (60) | 5 (25) | 3 (15) | |
| 2 | 23 (12) | 5 (21.7) | 8 (34.8) | 10 (43.5) | |
| 3 | 57 (29.7) | 5 (8.8) | 26 (45.6) | 26 (45.6) | |
| 4 | 81 (42.2) | 1 (1.2) | 18 (22.2) | 62 (76.5) | |
| AJCC ypN category | <0.001 | ||||
| 0 | 55 (28.6) | 22 (40) | 18 (32.7) | 15 (27.3) | |
| 1 | 36 (18.8) | 5 (13.9) | 12 (33.3) | 19 (52.8) | |
| 2 | 50 (26) | 4 (13.9) | 19 (38) | 27 (54) | |
| 3 | 51 (26.6) | 3 (5.9) | 8 (15.7) | 40 (78.4) | |
| AJCC stage | <0.001 | ||||
| 0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | |
| 1 | 24 (12.5) | 14 (58.3) | 7 (29.2) | 3 (12.5) | |
| 2 | 53 (27.6) | 7 (13.2) | 17 (32.1) | 29 (54.7) | |
| 3 | 106 (55.2) | 4 (3.8) | 33 (31.1) | 69 (65.1) | |
| R0 resection | 0.1 | ||||
| Yes | 159 (82.8) | 31 (19.5) | 49 (30.8) | 79 (49.7) | |
| No | 33 (17.2) | 3 (9.1) | 7 (21.2) | 23 (69.7) | |
| Adjuvant chemotherapy | 0.975 | ||||
| Not received | 59 (30.7) | 10 (16.9) | 17 (28.8) | 32 (54.2) | |
| Received | 133 (69.3) | 24 (18) | 39 (29.3) | 70 (52.6) | |