Table 7.
Univariate Cox regression analyses
| Characteristics | OS | PFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Gender | ||||||
| Male (reference) | 1 | 1 | ||||
| Female | 1.179 | 0.740–1.876 | 0.488 | 1.309 | 0.859–1.994 | 0.211 |
| Age | ||||||
| < 55y (reference) | 1 | 1 | ||||
| ≥ 55y | 1.120 | 0.903–1.390 | 0.303 | 0.856 | 0.577–1.270 | 0.441 |
| Location | ||||||
| Esophagogastric junction (reference) | 1 | 1 | ||||
| Proximal gastric | 0.952 | 0.555–1.632 | 0.857 | 0.829 | 0.506–1.358 | 0.456 |
| Distal gastric | 0.634 | 0.360–1.117 | 0.115 | 0.631 | 0.380–1.046 | 0.074 |
| Maximal diameter of tumor bed | 1.712 | 1.275–2.299 | <0.001 | 1.709 | 1.304–2.239 | <0.001 |
| Histological differentiation | 3.057 | 1.617–5.782 | 0.001 | 2.667 | 1.513–4.699 | 0.001 |
| Laurén classification | ||||||
| Intestinal (reference) | 1 | 1 | ||||
| Diffuse | 2.228 | 1.339–3.709 | 0.002 | 1.896 | 1.199–2.999 | 0.006 |
| Mixed | 2.206 | 1.216–4.003 | 0.009 | 1.911 | 1.113–3.280 | 0.019 |
| LVI | 3.318 | 2.089–5.270 | <0.001 | 3.324 | 2.180–5.069 | <0.001 |
| PNI | 2.878 | 1.750–4.733 | <0.001 | 2.724 | 1.737–4.271 | <0.001 |
| AJCC ypT category | 1.876 | 1.457–2.415 | <0.001 | 1.739 | 1.396–2.168 | <0.001 |
| AJCC ypN category | 1.946 | 1.572–2.408 | <0.001 | 1.918 | 1.578–2.330 | <0.001 |
| AJCC stage | 2.484 | 1.724–3.580 | <0.001 | 2.270 | 1.650–3.122 | <0.001 |
| Mandard-TRG | ||||||
| 1 (reference) | 1 | 1 | ||||
| 2 | 0.98 | 0.244–3.929 | 0.977 | 1.293 | 0.343–4.877 | 0.704 |
| 3 | 1.956 | 0.568–6.730 | 0.287 | 2.143 | 0.631–7.283 | 0.222 |
| 4 | 2.717 | 0.836–8.831 | 0.096 | 3.155 | 0.979–10.168 | 0.054 |
| 5 | 3.682 | 1.094–12.394 | 0.035 | 4.570 | 1.380–15.132 | 0.013 |
| JGCA-TRG | ||||||
| 3 (reference) | 1 | 1 | ||||
| 2 | 1.531 | 0.457–5.126 | 0.49 | 1.782 | 0.539–5.892 | 0.344 |
| 1b | 2.626 | 0.781–8.831 | 0.119 | 2.621 | 0.786–8.738 | 0.117 |
| 1a | 2.875 | 0.836–9.884 | 0.094 | 4.022 | 1.199–13.491 | 0.024 |
| 0 | 3.676 | 1.092–12.371 | 0.035 | 4.556 | 1.376–15.085 | 0.013 |
| CAP-TRG | ||||||
| 0 (reference) | 1 | 1 | ||||
| 1 | 0.979 | 0.244–3.927 | 0.977 | 1.292 | 0.343–4.873 | 0.705 |
| 2 | 1.953 | 0.568–6.719 | 0.288 | 2.140 | 0.630–7.272 | 0.223 |
| 3 | 2.996 | 0.937–9.586 | 0.064 | 3.558 | 1.119–11.311 | 0.032 |
| China-TRG | ||||||
| Severe response (reference) | 1 | 1 | ||||
| Moderate response | 1.719 | 0.808–3.657 | 0.160 | 1.661 | 0.834–3.308 | 0.149 |
| Mild response | 2.856 | 1.450–5.628 | 0.002 | 2.868 | 1.544–5.328 | 0.001 |
| Becker-TRG | ||||||
| 1a (reference) | 1 | 1 | ||||
| 1b | 0.980 | 0.244–3.927 | 0.977 | 1.292 | 0.343–4.872 | 0.705 |
| 2 | 2.216 | 0.673–7.294 | 0.190 | 2.295 | 0.702–7.502 | 0.169 |
| 3 | 3.109 | 0.964–10.028 | 0.058 | 3.964 | 1.239–12.681 | 0.020 |
| R0 resection | ||||||
| Yes (reference) | 1 | 1 | ||||
| No | 3.382 | 2.022–5.659 | <0.001 | 3.656 | 2.315–5.774 | <0.001 |
| Adjuvant chemotherapy | ||||||
| Not received (reference) | 1 | 1 | ||||
| Received | 1.040 | 0.633–1.707 | 0.878 | 1.227 | 0.774–1.943 | 0.384 |