Figure 3.

Dose–response contour for rule‐based and model‐based clinical trial designs. Doses explored relative to the dose–toxicity contour using a traditional, rule‐based method vs. a model‐based design. DLT, dose‐limiting toxicity. Trials based on rule‐based designs typically maintain the dose of one agent as a constant while escalating the dose of the other agent, resulting in a narrow exploration of the dose–toxicity contour. Trials utilizing model‐based designs may vary the doses of both agents to more comprehensively explore the dose–toxicity contour.