Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 30;9(2):74–88. doi: 10.1111/cts.12390

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Conceptual representation of nonlinear drug disposition and extrapolation from microdose to therapeutic dose for (a) drugs showing linear PK and (b) drugs showing nonlinear (saturable) PK at therapeutic dose. Width of the blue and orange bars schematically represents ranges of substrate drug concentration after microdose and therapeutic dose, respectively. AUC, area under the concentration‐time curve; CL, clearance; K_m, Michaelis‐Menten constant; [S], concentration of a substrate drug S.