Table 1.

Example topics of interest for Clinical and Translational Science

Translational medicine, including studies focused on interrogation/evaluation of mechanism‐of‐action, human physiology, and interruption of disease pathophysiology

Hypothesis generating nonclinical and clinical studies, including small clinical trials

Models of human disease and their therapeutic implications

Studies that guide Phase 2 dose selection

Studies that identify or support biomarkers that can be used at any stage of drug development

Studies that demonstrate effective communication between basic and clinical science

Regulatory and public health policy implications of translational studies

Pharmacokinetic/pharmacodynamic (PK/PD) and quantitative pharmacology as these relate to translational medicine

Precision medicine