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. 2016 Jan 12;9(1):29–35. doi: 10.1111/cts.12382

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© 2016 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Changes in exercise tolerance between combination therapy with sildenafil plus bosentan (S+B) and sildenafil plus ambrisentan (S+A). (a,b) Changes in 6‐minute walking distance (a) and externally paced 10 m shuttle walking distance (b) for each of the two combination treatments in each study participant. (c,d) Changes in peak oxygen consumption (c) and oxygen consumption at anaerobic threshold (d) assessed by cardiopulmonary exercise testing for each of the two coadministration treatments in each study participant. Open circle: associated‐pulmonary arterial hypertension; closed circle: idiopathic pulmonary arterial hypertension.