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. 2016 May 12;9(3):176–180. doi: 10.1111/cts.12398

Table 1.

Study end points

Assay Reagent Time point
Primary end point Peak thrombin generation PPP‐reagent low (Stago) 30 min after Kcentra/placebo infusion
Secondary end points

  • Thrombin generation

  1. Peak thrombin generation (0–72 h only);

  2. Endogenous thrombin potential;

  3. Lag time;

  4. Time to peak thrombin generation;

  5. mVRI.

  • PPP‐reagent low

  • PPP‐reagent

  • (Stago)

 30 min after Kcentra/placebo infusion and 0–72 h
Chromogenic anti‐factor Xa Biophen Heparin (Anaria)
PT PT reagent (Instrumentation Laboratory)
PTT APTT reagent (Instrumentation Laboratory)

mVRI, mean velocity rate index; PT, prothrombin time; PTT, partial thromboplastin time.