Table 2.

Thrombin generation geometric mean ratio end points 30 min after infusion of Kcentra or placebo

Reagent	Measure	Kcentra/ placebo GMR	Lower 95% CI	Upper 95% CI	p value
PPP low	Peak thrombin generation	1.76	1.09	2.83	0.025
PPP	Peak thrombin generation	1.76	1.19	2.60	0.009
PPP low	Endogenous thrombin potential	1.53	0.92	2.54	0.091
PPP	Endogenous thrombin potential	1.49	1.02	2.20	0.042
PPP low	Lag time	0.73	0.61	0.86	0.002
PPP	Lag time	0.72	0.62	0.85	0.001
PPP low	Time to peak thrombin generation	0.80	0.64	1.00	0.050
PPP	Time to peak thrombin generation	0.89	0.70	1.13	0.305
PPP low	mVRI	1.78	0.83	3.80	0.124
PPP	mVRI	1.62	0.91	2.89	0.094

CI, confidence interval; GMR, geometric mean ratio; mVRI, mean velocity rate index.