Table 5.

Thrombin generation parameters at 24, 48, and 72 h

Reagent	Measure	Hour	Kcentra/ Placebo GMR	Lower 95% CI	Upper 95% CI	p‐value
PPP low	Peak thrombin generation	24	1.24	0.87	1.77	0.239
PPP low	Peak thrombin generation	48	0.88	0.62	1.26	0.476
PPP low	Peak thrombin generation	72	0.71	0.50	1.02	0.065
PPP	Peak thrombin generation	24	1.24	1.08	1.42	0.003
PPP	Peak thrombin generation	48	1.09	0.95	1.25	0.210
PPP	Peak thrombin generation	72	1.03	0.90	1.18	0.677
PPP low	ETP	24	1.28	1.01	1.62	0.041
PPP low	ETP	48	0.96	0.76	1.22	0.740
PPP low	ETP	72	0.81	0.64	1.03	0.080
PPP	ETP	24	1.32	1.23	1.41	<0.001
PPP	ETP	48	1.20	1.12	1.28	<0.001
PPP	ETP	72	1.11	1.04	1.18	0.003
PPP low	Lag time	24	1.08	0.97	1.21	0.168
PPP low	Lag time	48	1.11	0.99	1.24	0.070
PPP low	Lag time	72	1.07	0.96	1.20	0.232
PPP	Lag time	24	1.02	0.93	1.11	0.725
PPP	Lag time	48	1.06	0.98	1.16	0.150
PPP	Lag time	72	1.01	0.93	1.11	0.733
PPP low	Time to peak thrombin generation	24	1.06	0.98	1.15	0.117
PPP low	Time to peak thrombin generation	48	1.11	1.03	1.20	0.008
PPP low	Time to peak thrombin generation	72	1.09	1.01	1.18	0.030
PPP	Time to peak thrombin generation	24	1.04	0.98	1.10	0.184
PPP	Time to peak thrombin generation	48	1.07	1.01	1.13	0.018
PPP	Time to peak thrombin generation	72	1.02	0.97	1.08	0.389
PPP low	mVRI	24	1.19	0.75	1.89	0.451
PPP low	mVRI	48	0.80	0.50	1.27	0.335
PPP low	mVRI	72	0.64	0.41	1.02	0.062
PPP	mVRI	24	1.17	0.95	1.42	0.131
PPP	mVRI	48	1.03	0.84	1.25	0.790
PPP	mVRI	72	1.00	0.82	1.22	0.999

CI, confidence interval; ETP, endogenous thrombin potential; GMR, geometric mean ratio; mVRI, mean velocity rate index.