Table I.
Baseline general characteristics among all patients and by mean EGFR score index punctuation.
| Mean EGFR-score index punctuation | Mean EGFR-score index punctuation | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Overall (n=85) | Mean (± SD; mean EGFR) score=125.41±96.36 | P-value | <100 (n=39) | ≥100 (n=46) | P-value | <200 (n=61) | ≥200 (n=24) | P-value |
| Gender | 0.096 | 0.048a | 0.123a | ||||||
| Male | 42.4 (36/85) | 105.09 (±88.18) | 53.8 (21/39) | 32.6 (15/46) | 47.5 (29/61) | 29.2 (7/24) | |||
| Female | 57.6 (49/85) | 140.34 (±100.21) | 46.2 (18/39) | 67.4 (31/46) | 52.5 (32/61) | 70.8 (17/24) | |||
| Mean age (± SD) | 61.76 (12.97) | – | – | 62.3 (13.88) | 61.28 (12.28) | 0.712b | 62.54 (13.67) | 59.79 (11.02) | 0.382a |
| Median age, years | 0.231 | 0.849a | 0.113a | ||||||
| <60 | 44.7 (38/85) | 138.38 (±97.82) | 43.6 (17/39) | 45.7 (21/46) | 39.3 (24/61) | 58.3 (14/24) | |||
| ≥60 | 55.3 (47/85) | 114.11 (±94.69) | 56.4 (22/39) | 54.3 (25/46) | 60.7 (37/61) | 41.7 (10/24) | |||
| Smoking exposure | 0.252 | 0.288a | 0.106a | ||||||
| Non-smoker | 40.0 (34/85) | 141.47 (±108.33) | 33.3 (13/39) | 45.7 (21/46) | 34.4 (21/61) | 54.2 (13/24) | |||
| Smoker | 60.0 (51/85) | 116.86 (±86.44) | 66.6 (26/39) | 54.3 (25/46) | 65.6 (40/61) | 45.8 (11/24) | |||
| Tobacco index | 0.384b | 0.696b | |||||||
| Mean (± SD) | 27.57 (36.67) | – | – | 22.99 (18.44) | 32.16 (48.78) | 26.48 (30.70) | 31.45 (55.04) | ||
| Wood-smoke exposure | 0.488 | 0.514a | 0.936a | ||||||
| Absent | 57.6 (49/85) | 131.66 (±88.74) | 53.8 (21/39) | 60.9 (28/46) | 57.4 (35/61) | 58.3 (14/24) | |||
| Present | 42.4 (36/85) | 116.89 (±106.55) | 46.2 (18/39) | 39.1 (18/46) | 42.6 (26/61) | 41.7 (10/24) | |||
| Wood-smoke index | 0.193b | 0.696b | |||||||
| Mean (± SD) | 90.41 (100.68) | – | – | 68.38 (72.94) | 112.44 (120.50) | 73.18 (81.17) | 135.20 (134.28) | ||
| Asbestos exposure | 0.131 | 0.155a | 0.976a | ||||||
| Absent | 83.5 (71/85) | 118.38 (±97.45) | 89.7 (35/39) | 78.3 (36/46) | 83.6 (51/61) | 83.3 (20/24) | |||
| Present | 16.5 (14/85) | 161.07 (±84.99) | 10.3 (4/39) | 21.7 (10/46) | 16.4 (10/61) | 16.7 (4/24) | |||
| Histology | 0.974 | 0.883a | 0.344a | ||||||
| Adenocarcinoma | 77.6 (66/85) | 125.22 (±97.14) | 76.9 (30/39) | 78.3 (36/46) | 80.3 (49/61) | 70.8 (17/24) | |||
| Other | 22.4 (19/85) | 126.05 (±96.18) | 23.1 (9/39) | 21.7 (10/46) | 19.7 (12/61) | 29.2 (7/24) | |||
| Disease stage | 0.776 | 0.614a | 0.882a | ||||||
| II–III | 17.6 (15/85) | 131.73 (±93.90) | 15.4 (6/39) | 19.6 (9/46) | 18.0 (11/61) | 16.7 (4/24) | |||
| IV | 82.4 (70/85) | 124.02 (±97.48) | 84.6 (33/39) | 80.4 (37/46) | 82.0 (50/61) | 83.3 (20/24) | |||
| ECOG PS | 0.131 | 0.227a | 0.158a | ||||||
| 0–1 | 82.4 (70/85) | 132.73 (±95.96) | 76.9 (30/39) | 87.0 (40/46 | 78.7 (48/61) | 91.7 (22/24) | |||
| 2–3 | 17.6 (15/85) | 91.22 (±93.80) | 23.1 (9/39) | 13.0 (6/46) | 21.3 (13/61) | 8.3 (2/24) | |||
| Pleural effusion | 0.396 | 0.406a | 0.515a | ||||||
| Yes | 61.2 (52/33) | 132.53 (±93.26) | 56.4 (22/39) | 65.2 (30/46) | 59.0 (36/61) | 66.7 (16/24) | |||
| No | 38.8 (33/85) | 114.19 (±101.48) | 43.6 (17/39) | 38.4 (16/46) | 41.0 (25/61) | 33.3 (8/24) | |||
| PB-CT | 0.955 | 0.748a | 0.969a | ||||||
| No | 24.7 (21/85) | 124.36 (±106.61) | 23.1 (9/39) | 26.1 (12/46) | 24.6 (16/61) | 25.0 (6/24) | |||
| Yes | 75.3 (64/85) | 125.75 (±95.40) | 76.9 (30/39) | 73.9 (34/46) | 75.4 (46/61) | 75.0 (18/24) | |||
| DCR with PB-CT | 0.102 | 0.265a | 0.697a | ||||||
| Yes | 30.6 (26/64) | 149.35 (±95.09) | 33.3 (10/30) | 47.1 (16/34) | 39.1 (18/46) | 44.4 (8/18) | |||
| No | 44.7 (38/64) | 109.60 (±93.43) | 66.7 (20/30) | 52.9 (18/34) | 60.9 (28/46) | 55.6 (10/18) | |||
| TKI | 0.287 | 0.227a | 0.158a | ||||||
| No | 82.4 (70/85) | 130.59 (±99.63) | 76.9 (30/39) | 87.0 (40/46) | 78.7 (48/61) | 91.7 (22/24) | |||
| Yes | 17.6 (15/85) | 101.22 (±77.61) | 23.1 (9/39) | 13.0 (6/46) | 21.3 (13/61) | 8.3 (2/24) | |||
| DCR with TKI | 0.818 | 1.000a | 0.283a | ||||||
| Yes | 33.3 (5/15) | 94.33 (±79.00) | 33.3 (3/9) | 33.3 (2/6) | 38.5 (5/13) | 0.0 (0/2) | |||
| No | 66.7 (10/15) | 104.66 (±80.98) | 66.7 (6/9) | 66.7 (4/6) | 61.5 (8/13) | 100.0 (2/2) | |||
a
Students t-test
b
χ2 test. Wood-smoke index=years exposed × no. of hours exposed. Tobacco smoke index=[(no. of cigarettes smoked per day) × (no. of years smoking)] / 20. EGFR, epidermal growth factor receptor; ECOG PS, eastern cooperative oncology group performance status; DCR, disease control rate; PB, platinum-based; CT, chemotherapy; TKI, tyrosine kinase inhibitor.