Figure 3.

Effect of different treatment modalities on CAIX expression-associated fluorescence. (A) Representative subcutaneous tumor model imaging of light intensity of HypoxiSense 680 distribution subsequent to tail-vein injection. The groups were control, danshensu at 60 mg/kg, RT (10 Gy each) and danshensu + RT. The fluorescent reagent was stably expressed in the hypoxia regions and was degraded in the normal oxygen regions. All the images were represented under the same color scale. (B) The photon counts of the tumor area in treated mice. The photon counts of danshensu + RT were much lower compared with the other 3 groups. Data are expressed as the mean ± standard deviation. CAIX, carbonic anhydrase IX; RT, radiation therapy.