Table 2. . Observed physicochemical properties of mangiferin.
| Parameter | Predicted values from GastroPlus® | Experimental value | p-value | Reported values from literature | Ref. |
|---|---|---|---|---|---|
| Aqueous solubility |
1.44 mg/ml |
0.38 mg/ml at 25°C |
< 0.001† |
0.25 mg/ml at 45°C |
[39] |
| Fasted-state simulated gastric fluid |
0.133 mg/ml |
0.140 mg/ml at 25°C |
> 0.05 (NS) |
Not reported in literature |
– |
| Fasted-state simulated intestinal fluid |
1.51 mg/ml |
1.48 mg/ml at 25°C |
> 0.05 (NS) |
Not reported in literature |
– |
| Fed-state simulated intestinal fluid |
4.67 mg/ml |
3.98 mg/ml at 25°C |
< 0.001† |
Not reported in literature |
– |
| Melting point |
– |
274°C |
– |
270°C |
[40] |
| log P |
-0.59 |
-0.65 |
> 0.05 (NS) |
-0.09 to -0.36 |
[41] |
| log D |
-0.80 |
-0.79 |
> 0.05 (NS) |
Not reported in literature |
– |
| Peff |
0.27 × 10-4 cm/s |
0.16 × 10-4 cm/s |
< 0.01‡ |
Not reported in literature |
– |
| P-gp substrate | Yes | Yes | – | Yes | [14,42] |
Observed values are mean of three values.
†Appreciable significant difference.
‡Significant difference.
log P: partition coefficient; log D: distribution coefficient; NS: Not significant; Peff: Effective permeability.