Table 1. Characteristics of case-control studies on microRNA polymorphisms and CHD risk included in the meta-analysis.

First author	Year	Country/Region	Ethnicity	Source of controls	Case	Control	Genotype distribution						Genotyping methods	Age and sex matched	P for HWEa
							Case			Control
microRNA-146a rs2910164 G>C							CC	GC	GG	CC	GC	GG
Sung JH	2016	Korea	Asian	Hospital	522	535	203	242	77	202	260	73	PCR-RFLP	matched	0.460
Bastami M	2016	Iran	Caucasian	NA	300	300	34	155	111	22	128	150	Taqman	matched	0.454
Huang SL	2015	China	Asian	Hospital	722	721	266	308	143	237	348	132	Taqman	matched	0.830
Xiong XD	2014	China	Asian	Hospital	295	283	113	141	41	97	125	61	PCR-RFLP	unmatched	0.086
Prithiksha R	2014	South Africa	Asian	NA	106	100	13	43	50	9	46	45	PCR-RFLP	matched	0.569
Chen CR	2014	China	Asian	Hospital	919	889	187	463	269	153	435	301	PCR-LDR	unmatched	0.846
Hamann L	2014	Germany	Caucasian	Population	206	200	12	74	120	10	73	117	PCR-HRM	unmatched	0.748
Chen L	2013	China	Asian	Hospital	658	658	172	305	181	134	330	194	Taqman	matched	0.769
Yang Y-a	2012	China	Asian	Population	853	948	272	392	165	271	457	189	Taqman	matched	0.885
Li L	2012	China	Asian	Hospital	415	1010	149	184	82	345	455	210	PCR-RFLP	unmatched	0.009
microRNA-196a2 rs11614913 T>C							CC	TC	TT	CC	TC	TT
Sung JH	2016	Korea	Korean	Hospital	522	535	107	236	179	108	274	153	PCR-RFLP	matched	0.465
Huang SL	2015	China	Asian	Hospital	722	721	147	381	190	156	360	204	Taqman	matched	0.905
Xiong XD	2014	China	Asian	Hospital	295	283	78	131	86	68	132	83	PCR-RFLP	unmatched	0.278
Chen CR	2014	China	Asian	Hospital	919	889	157	450	312	161	406	322	PCR-LDR	unmatched	0.097
Zhi H	2012	China	Asian	Hospital	916	584	155	470	291	98	278	208	PCR-RFLP	matched	0.755
Yang Y-a	2012	China	Asian	Population	853	948	163	463	202	217	463	241	Taqman	matched	0.853
Yang Y-b	2012	China	Asian	Population	1919	1840	433	971	493	389	921	528	Taqman	matched	0.734
microRNA-499 rs3746444 G>A							GG	AG	AA	GG	AG	AA
Sung JH	2016	Korea	Korean	Hospital	522	535	9	155	358	13	168	354	PCR-RFLP	matched	0.182
Xiong XD	2014	China	Asian	Hospital	295	283	3	65	227	4	67	212	PCR-RFLP	unmatched	0.616
Chen CR	2014	China	Asian	Hospital	919	889	70	237	612	37	246	606	PCR-LDR	unmatched	0.062
Chen L	2013	China	Asian	Hospital	658	658	46	149	463	26	158	474	Taqman	matched	0.007
Zhi H	2012	China	Asian	Hospital	916	584	86	201	629	21	167	396	PCR-RFLP	matched	0.517
Yang Y-a	2012	China	Asian	Population	853	948	28	210	589	28	212	683	Taqman	matched	0.023
microRNA-149 rs71428439 G>A							GG	AG	AA	GG	AG	AA
Chen CR	2014	China	Asian	Hospital	919	889	155	389	375	124	381	384	PCR-LDR	unmatched	0.062
Ding SL	2013	China	Asian	NA	289	296	64	130	95	38	126	132	PCR-DNA sequencing	matched	0.360

CHD: coronary heart disease. HWE: Hardy-Weinberg equilibrium. ^a HWE in control. NA: not available