Table 3. Genes differentially expressed in human PPFP thyroid carcinomas have the same trend in differential expression in PPFP^Thy;Pten^Thy−/− mice versus Pten^Thy-/- control mice.

	human PPFP carcinomas repressed	human PPFP carcinomas induced	total
PPFPThy;PtenThy−/− mice repressed	45	79	124
PPFPThy;PtenThy−/− mice induced	19	90	109
total	64	169	233

Fisher's exact test, two-tailed p = 0.0019.

Of 275 genes differentially expressed in human PPFP thyroid carcinomas versus non-PPFP thyroid carcinomas and normal thyroids [8], 267 have mouse homologs and 34 have negligible expression in mouse thyroid, leaving 233 genes for analysis. We define mouse genes to be induced if log fold change > 0, and repressed if log fold change < 0.