Skip to main content
. 2016 Dec 13;8(4):5895–5908. doi: 10.18632/oncotarget.13927

Figure 4. ATP exerts a direct toxicity on LSCs.

Figure 4

(A) Flow cytometric analysis of P2×7 expression on leukemic stem progenitor subsets (n = 22). (B) ApoTox-Glo Triplex assay showing the viability, the cytotoxicity (RFU) and apoptosis (CPS) of highly purified LSC subsets treated with 5 mM ATP for 48 h. Results from cytotoxicity and Caspase-3/7 activity assay are expressed as fold-change of RFU and CPS, respectively. Untreated cells are used as reference and set as 1. Data are represented as mean +/− SEM (n = 4). *p < 0.05, **p < 0.01.