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. 2016 Dec 15;8(4):5943–5953. doi: 10.18632/oncotarget.13966

Figure 5. Mice growth decreases the expression levels of imprinting genes in the skeletal muscle.

Figure 5

Quantitative RT-PCR showing the decreased expression of miR-411 (A) miR-540-3p (B) pri-miR-411 (C) and Gtl2 (D) in both wild-type and myostatin knockout mice with age. (E) The expression level of Igf2, the growth-related imprinting gene, is also decreased in the skeletal muscle as mice grow. (F) The expression of miR-486 that is increased in myostatin knockout mice is not changed with age. The expression level of either U6 or Rpl26 was used to normalize the qRT-PCR results. Data are the mean ± SD (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001.