Table 4. SLR versus CFRT or SBRT for high-risk elderly Stage I NSCLC: a meta-analysis of pattern of failures.
| End point | No. of studies | No. of patients | OR | 95% CI | Significance | Publication bias | Heterogeneity |
|---|---|---|---|---|---|---|---|
| SLR versus CFRT | |||||||
| LF | 3 | 185 | 1.09 | 0.50–2.36 | 0.84 | 1.00 | 0.69 |
| RL | 1 | 84 | 0.82 | 0.20–3.33 | 0.79 | ||
| DF | 2 | 150 | 0.74 | 0.27–1.98 | 0.54 | 0.84 | |
| LRF | 1 | 84 | 0.72 | 0.26–1.98 | 0.53 | ||
| SLR versus SBRT | |||||||
| LF | |||||||
| All studies combined | 6 | 622 | 0.83 | 0.23–3.02 | 0.78 | 0.46 | 0.008 |
| PSM analysis | 2 | 137 | 0.68 | 0.11–4.31 | 0.68 | 0.16 | |
| None PSM analysis | 4 | 485 | 0.83 | 0.17–3.96 | 0.81 | 0.73 | 0.003 |
| RF | |||||||
| All studies combined | 3 | 264 | 1.08 | 0,66–7.03 | 0.94 | 0.30 | 0.03 |
| PSM analysis | 2 | 137 | 2.29 | 0.60–8.81 | 0.23 | 0.28 | |
| None PSM analysis | 1 | 127 | 0.23 | 0.06–0.87 | 0.03 | ||
| DF | |||||||
| All studies combined | 6 | 716 | 1.36 | 0.88–2.11 | 0.16 | 0.09 | 0.25 |
| PSM analysis | 3 | 322 | 2.79 | 1.10–7.06 | 0.03 | 0.44 | |
| None PSM analysis | 3 | 394 | 1.05 | 0.63–1.76 | 0.84 | 0.55 | |
| LRF | |||||||
| All studies combined | 4 | 449 | 0.77 | 0.22–2.47 | 0.69 | 0.73 | 0.007 |
| PSM analysis | 3 | 322 | 1.12 | 0.53–2.40 | 0.76 | 0.18 | |
| None PSM analysis | 1 | 127 | 0.18 | 0.07–0.48 | 0.001 | ||
Abbreviations: CFRT: conventional fractionated radiotherapy; PSM: propensity-score matched; SBRT: stereotactic body radiation therapy; SLR: sublobar resection; OR: Odds ratio; CI: confidence interval; LF: local failure; RF: regional failure; DF: distant failure; LRF: locoregional failure.