Table 2. Combination activity of melflufen and cytarabine or daunorubicin in HL-60 for selected concentrations (calculated according to the multiplicative Bliss model).

Concentrationmelflufen(μM)	Concentrationcytarabine(μM)	Concentrationdaunorubicin(μM)	PI melflufen(%)	PIcytarabine(%)	PIcombination(%)	PIcombinationpredicted	Interaction
0.030	0.25	NA	47	30	71	63	S
0.030	0.50	NA	47	45	83	71	S
0.063	0.25	NA	71	30	83	79	S
0.063	0.50	NA	71	45	88	84	S
0.030	NA	0.013	47	40	54	68	SA
0.030	NA	0.025	47	58	71	77	SA
0.063	NA	0.013	71	40	74	83	SA
0.063	NA	0.025	71	58	78	88	SA

Abbreviations: PI; percent inhibition, S; Synergy, SA; Subadditive interaction.