Table 2. Pharmacologic inhibition of MRP4 increases sensitivity to 6-MP.
Pharmacologic Treatment | μM | Fold Sensitizationa | |
---|---|---|---|
MDA-MB-231 | |||
MK571 | 50 | 2.94 | * |
MDA-MB-436 | |||
MK571 | 25 | 1.47 | * |
Tyrphostin AG 1478 | 10 | 2.86 | ** |
BT549 | |||
MK571 | 50 | 1.76 | ** |
Tyrphostin AG 1478 | 10 | 4.83 | ** |
aSensitization by MRP4 inhibitors relative to vehicle treatment
* p < 0.05, ** p < 0.01