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. 2016 Dec 25;8(4):6564–6578. doi: 10.18632/oncotarget.14169

Figure 8. Mice were sacrificed at 4 weeks to evaluate the brain size and weight, and histopathological changes.

Figure 8

In contrast to normal mouse (A, upper panel), untreated glioma mice (A, lower panel) exhibited tumor growth, largely increasing the brain size. Tumor growth was prevented by RVG-PTX-NPs (A, middle panel), leading to comparable brain size to the normal control. The brain sections were histopathologically evaluated by antibody to GFP to identify the GFP-U87 cells (B and C, brown). Representative images revealed significant prevention of U87 growth in RVG-PTX-NPs treated glioma mice (B) compared to untreated group (C). The body D. and tumor E. weight were measured to determine the body loss and tumor growth for evaluation of the anti-glioma efficacy.