Table 1. Non-silent somatic mutations identified in the cancer Census Genes.
| Gene | Case | Exonic function | cDNA Change | Amino acid |
|---|---|---|---|---|
| APC | HGCA 1 | frameshift | c.4385_4386delAG | p.K1462fs |
| HGCA 1 | missense | c.1958G>A | p.R653K | |
| HGCA 2 | nonsense | c.1660C>T | p.R554X | |
| HGCA 2 | nonsense | c.4189G>T | p.E1397X | |
| HGCA 3 | frameshift | c.4385_4386delAG | p.K1462fs | |
| HGCA 5 | nonsense | c.847C>T | p.R283X | |
| HGCA 5 | nonsense | c.4067C>A | p.S1356X | |
| HGCA 6 | nonsense | c.4348C>T | p.R1450X | |
| HGCA 6 | nonsense | c.3340C>T | p.R1114X | |
| HGCA 7 | nonsense | c.4222G>T | p.E1408X | |
| HGCA 7 | nonsense | c.3340C>T | p.R1114X | |
| HGCA 8 | nonsense | c.1690C>T | p.R564X | |
| HGCA 9 | nonsense | c.3093T>A | p.Y1031X | |
| HGCA 9 | nonsense | c.4348C>T | p.R1450X | |
| HGCA 11 | nonsense | c.3871C>T | p.Q1291X | |
| HGCA 11 | nonsense | c.2626C>T | p.R876X | |
| HGCA 12 | nonsense | c.694C>T | p.R232X | |
| HGCA12 | nonsense | c.2413C>T | p.R805X | |
| KRAS | HGCA 2 | missense | c.35G>T | p.G12V |
| HGCA 3 | missense | c.35G>A | p.G12D | |
| HGCA 5 | missense | c.35G>T | p.G12V | |
| HGCA 7 | missense | c.35G>A | p.G12D | |
| HGCA 8 | missense | c.34G>T | p.G12C | |
| HGCA 9 | missense | c.34G>A | p.G12S | |
| HGCA 10 | missense | c.38G>A | p.G13D | |
| SMAD4 | HGCA 1 | missense | c.1082G>A | p.R361H |
| HGCA 6 | missense | c.1212C>A | p.D404E | |
| HGCA 10 | missense | c.1156G>A | p.G386S | |
| ERBB4 | HGCA 4 | missense | c.1753G>T | p.D585Y |
| HGCA 9 | nonsense | c.2224G>T | p.E742X | |
| TCF7L2 | HGCA 5 | nonsense | c.70G>T | p.E24X |
| HGCA 11 | frameshift | c.463delA | p.K155fs | |
| AMER1 | HGCA 6 | nonsense | c.1072C>T | p.R358X |
| HGCA 9 | nonsense | c.1240C>T | p.Q414X | |
| TP53 | HGCA 9 | missense | c.524G>A | p.R175H |
| HGCA 11 | missense | c.747G>C | p.R249S | |
| GNAS | HGCA 2 | missense | c.601C>T | p.R201C |
| ARID2 | HGCA 2 | nonsense | c.3817C>T | p.R1273X |
| RET | HGCA 3 | missense | c.1267G>A | p.G423R |
| MTOR | HGCA 4 | missense | c.6644C>T | p.S2215F |
| NRAS | HGCA 4 | missense | c.183A>C | p.Q61H |
| ACVR1B | HGCA 4 | missense | c.101G>A | p.C34Y |
| GNAQ | HGCA 7 | missense | c.286A>T | p.T96S |
| ATM | HGCA 8 | missense | c.1010G>A | p.R337H |
| PIK3CA | HGCA 10 | missense | c.3140A>G | p.H1047R |
| ERBB2 | HGCA 12 | missense | c.2524G>A | p.V842I |
| TRRAP | HGCA 12 | missense | c.10751T>A | p.V3584E |
| MAP2K4 | HGCA 12 | missense | c.881G>A | p.G294E |
| MAP3K4 | HGCA 12 | missense | c.4577C>T | p.A1526V |
| CNOT1 | HGCA 12 | missense | c.7048G>A | p.E2350K |
| EP300 | HGCA12 | nonsense | c.3934C>T | p.R1312X |
HGCA: high-grade colon adenoma