Table 3. Association between alcohol consumption behavior and ALDH2 rs671 polymorphism and gastric cancer risk, with regards to each other.
| Case(%) | Control(%) | Minimally Adjusteda | Fully Adjustedb | P value* | ||
|---|---|---|---|---|---|---|
| OR(95% CI) | OR(95% CI) | |||||
| NCC only | ||||||
| ALDH2 genotype AA/AG | ||||||
| Never/Rare & Light drinkers (<20 g/day) | 117(86.67) | 296(94.27) | 1.00(reference) | 1.00(reference) | 0.80 | |
| Heavy drinkers (≥20 g/day) | 18(13.33) | 18(5.73) | 2.01(0.99-4.08) | 2.02(0.86-4.77) | ||
| ALDH2 genotype GG | ||||||
| Never/Rare & Light drinkers (<20 g/day) | 156(57.14) | 580(78.80) | 1.00(reference) | 1.00(reference) | ||
| Heavy drinkers (≥20 g/day) | 117(42.86) | 156(21.20) | 2.47(1.73-3.54) | 1.59(1.03-2.45) | ||
| Never/Rare & Light drinkers (<20 g/day) | ||||||
| GG | 156(57.14) | 580(66.21) | 1.00(reference) | 1.00(reference) | ||
| AA/AG | 117(42.86) | 296(33.79) | 1.34(1.01-1.79) | 1.40(0.99-1.98) | ||
| Heavy drinkers (≥20 g/day) | ||||||
| GG | 117(86.67) | 156(89.66) | 1.00(reference) | 1.00(reference) | ||
| AA/AG | 18(13.33) | 18(10.34) | 1.36(0.67-2.76) | 1.61(0.68-3.82) | ||
| NCC+KoGES control | ||||||
| ALDH2 genotype AA/AG | ||||||
| Never/Rare & Light drinkers (<20 g/day) | 117(86.67) | 1647(95.09) | 1.00(reference) | 1.00(reference)c | 0.99 | |
| Heavy drinkers (≥20 g/day) | 18(13.33) | 85(4.91) | 2.02(1.16-3.53) | 1.78(0.96-3.29) | ||
| ALDH2 genotype GG | ||||||
| Never/Rare & Light drinkers (<20 g/day) | 156(57.14) | 3368(79.98) | 1.00(reference) | 1.00(reference)c | ||
| Heavy drinkers (≥20 g/day) | 117(42.86) | 843(20.02) | 2.47(1.83-3.34) | 2.19(1.58-3.03) | ||
| Never/Rare & Light drinkers (<20 g/day) | ||||||
| GG | 156(57.14) | 3368(67.16) | 1.00(reference) | 1.00(reference)c | ||
| AA/AG | 117(42.86) | 1647(32.84) | 1.41(1.10-1.82) | 1.34(1.02-1.75) | ||
| Heavy drinkers (≥20 g/day) | ||||||
| GG | 117(86.67) | 843(90.84) | 1.00(reference) | 1.00(reference)c | ||
| AA/AG | 18(13.33) | 85(9.16) | 1.52(0.89-2.63) | 1.28(0.70-2.35) | ||
Abbreviations: OR, Odds Ratio; CI, Confidence Interval; NCC, National Cancer Center; KoGES, Korean Genome Epidemiology Study;
a Adjusted for age and sex.
b Adjusted for age, sex, smoking status, education level, income, fruit/vegetable intake, H. pylori infection status, and family history of gastric cancer.
c Adjusted for age, sex, smoking status, education level, income, family history of gastric cancer, and study sites.
* p value for Cochran-Mantel-Haenszel test.