Table 4. Association between H. pylori infection and gastric cancer risk, stratified by alcohol drinking status/ALDH2 rs671 genotype.
| Case(%) | Control(%) | Minimally Adjusteda | Fully Adjustedb | P value* | ||
|---|---|---|---|---|---|---|
| OR(95% CI) | OR(95% CI) | |||||
| H. pylori infection x Alcohol drinking status | ||||||
| Negative | Never/Rare & Light drinkers (<20 g/day) | 22(62.86) | 349(84.91) | 1.00(reference) | 1.00(reference) | 0.35 |
| Heavy drinkers (≥20 g/day) | 13(37.14) | 62(15.09) | 2.95(1.18-7.40) | 1.72(0.53-5.58) | ||
| Positive | Never/Rare & Light drinkers (<20 g/day) | 251(67.29) | 527(82.47) | 1.00(reference) | 1.00(reference) | |
| Heavy drinkers (≥20 g/day) | 122(32.71) | 112(17.53) | 1.99(1.44-2.75) | 1.50(1.04-2.16) | ||
| P for interaction | 0.49 | 0.71 | ||||
| H. pylori infection x ALDH2 polymorphism | ||||||
| Negative | GG | 24(63.16) | 296(72.02) | 1.00(reference) | 1.00(reference) | 0.33 |
| AA/AG | 14(36.84) | 115(27.98) | 1.48(0.73-3.02) | 1.93(0.83-4.48) | ||
| Positive | GG | 280(67.96) | 440(78.71) | 1.00(reference) | 1.00(reference) | |
| AA/AG | 132(32.04) | 199(21.29) | 0.96(0.73-1.27) | 1.10(0.80-1.51) | ||
| P for interaction | 0.27 | 0.23 | ||||
Abbreviations: OR, Odds Ratio; CI, confidence Interval;
a Adjusted for age and sex.
b Adjusted for age, sex, smoking status, education level, income, fruit/vegetable intake, and family history of gastric cancer.
* p value for Cochran-Mantel-Haenszel test.