Figure 1. Cordycepin triggers caspase-dependent apoptosis in NSCLC.

A. Cell viability of H1792, A549, H1299, H157 and H460 cells was measured by SRB assay after treated with the indicated concentrations of cordycepin for 24 h and 48 h. B. Flow cytometry analysis was performed in H460 and H1299 cell lines after treated with the indicated concentrations of cordycepin for 24 h. The indicated cells were treated with different concentrations of cordycepin for 12 h C. or exposed to 100 μM cordycepin for the indicated time D., thereafter whole cell lysates were collected for Western blot analysis. Data were normalized to control and represented mean ± SEM for three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.001).