Figure 6. The schematic model of cordycepin-triggered apoptosis and autophagy in human NSCLC cells.

Cordycepin treatment stimulates extrinsic apoptosis pathway by inhibiting the expression of c-FLIPL. Furthermore, cordycepin also triggered autophagy through suppression of mTOR signaling pathway. Cordycepin-induced autophagy promoted apoptosis through degrading c-FLIPL.