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. 2016 Dec 28;8(4):6970–6983. doi: 10.18632/oncotarget.14344

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Copyright: © 2017 Yamazaki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Kaplan–Meier method for the two groups in the training cohort using frozen tissue that showed both higher and lower miR-181c expressions. The threshold was established using the ROC curve and Youden index. RFS was significantly worse for the patients with higher miR-181c expression than for those with lower miR-181c expression of. B. Kaplan–Meier method for the two groups in the training cohort using FFPE tissue that showed both higher and lower miR-181c expressions. The threshold was established using the ROC curve and Youden index. RFS was significantly worse for the patients with higher miR-181c expressions than for those with lower miR-181c expressions. C. Kaplan–Meier method for the two groups in the validation cohort that showed both high and low miR-181c expressions. The threshold was 0.010, which was established in the training cohort. RFS was significantly worse for the patients with higher miR-181c expression than for those with lower miR-181c expressions. The differences were analyzed by log-rank test. P < 0.05 denotes a statistically significant difference.