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. 2016 Sep 29;8(4):7025–7038. doi: 10.18632/oncotarget.12347

Figure 2. Differential localization of mucins in colorectal polyp subtypes.

Figure 2

Differential localization pattern for MUC5AC and MUC4 were observed for polyp subtypes. MUC5AC expression was absent in normal colon, restricted to the goblet cells (GC) in HP, and present in the goblet cells and lumen of colon crypts in SSA/P. In case of TA, the MUC5AC expression was observed in goblet cells but at lower intensity. In normal colon, MUC4 expression was observed throughout the colon crypts (CC) while it was absent on luminal surface epithelium (LE). In the HP and TA, MUC4 expression was observed throughout CC including luminal epithelium. In contrast to this, in 30% SSA/P cases, MUC4 expression was limited to lower one-third of colon crypts. The differential localization pattern of MUC4 and MUC5AC could provide useful molecular adjunct to histological classification of colorectal polyps. CC: colon crypts; GC: goblet cells; LE: luminal surface epithelium; HP: hyperplastic polyps; SSA/P: sessile serrated adenoma/polyps; TA: tubular adenoma.