Table 3. Expression of mucins and associated O-glycans in different colorectal polyp subtypes and corresponding adjacent normal colon.
NC | HP | NC | SSA/P | NC | TA | ||
---|---|---|---|---|---|---|---|
MUC1 | Mean ± SE | 0.25±0.07 e | 0.76 ± 0.09 b | 0.09±0.02 l | 0.53 ± 0.09 c,h | 0.28±0.05 i | 1.02 ± 0.09 c,k |
Median (Min, Max) | 0.1(0,1.4) | 0.6(0.1, 2.1) | 0.05(0, 0.3) | 0.4(0.05, 2.4) | 0.2(0, 1) | 1(0.1, 2.4) | |
MUC4 | Mean ± SE | 1.87±0.11 | 1.66 ± 0.12 k | 1.63±0.15 l | 1.05 ± 0.12 c,e | 1.25±0.12 | 1.21 ± 0.12 |
Median (Min, Max) | 2.1(0.2, 2.55) | 1.8(0.3, 2.7) | 1.8(0.1, 2.4) | 1(0.05, 2.7) | 1.2(0.05, 2.4) | 1.3(0.1, 2.4) | |
MUC17 | Mean ± SE | 0.11±0.03 f | 0.37 ± 0.05 c,l | 0.06±0.02 l | 0.85 ± 0.08 c,f,g | 0.24±0.05 | 0.47 ± 0.07 j |
Median (Min, Max) | 0.05(0, 0.7) | 0.2(0.05, 1.2) | 0(0, 0.3) | 1(0.05, 2.1) | 0.1(0, 1.2) | 0.4(0, 1.4) | |
MUC2 | Mean ± SE | 2.31±0.09 | 2.09 ± 0.09 h | 2.26±0.09 k | 1.92 ± 0.08 b,g | 2.21±0.06 i | 1.35 ± 0.14 c,e,j |
Median (Min, Max) | 2.4(1.2, 2.7) | 2.4(0.75, 2.7) | 2.4(0.9, 2.7) | 1.8(1.2, 2.7) | 2.4(1, 2.7) | 1.3(0.1, 2.7) | |
MUC5AC | Mean ± SE | 0±0 f | 0.65 ± 0.08 c,l,i | 0±0 l | 1.24 ± 0.09 c,f,i | 0.03±0.02 i | 0.3 ± 0.08 c,f,l |
Median (Min, Max) | 0(0, 0) | 0.6(0.15, 2.1) | 0(0, 0) | 1.2(0.15, 2.4) | 0(0, 0.6) | 0.06(0, 2.1) | |
Tn/STn-MUC1 | Mean ± SE | 0.23±0.05 f | 1.42 ± 0.07 c | 0.17±0.05 l | 1.39 ± 0.08 c | 0.39±0.05 i | 1.13 ± 0.1 c |
Median (Min, Max) | 0.1(0, 0.8) | 1.4(0.6, 2.7) | 0(0, 0.8) | 1.4(0.3, 2.4) | 0.3(0, 1.6) | 1.2(0, 2.4) | |
CA19-9 | Mean ± SE | 0.1±0.05 f | 1.53 ± 0.17 c,i | 0.04±0.02 l | 1.72 ± 0.13 c,i | 0.02±0.01 i | 0.1 ± 0.03 c,f,l |
Median (Min, Max) | 0(0, 1.2) | 1.8(0, 2.7) | 0(0, 0.4) | 2.1(0, 2.7) | 0(0, 0.3) | 0(0, 0.6) |
ap < 0.05 vs. adjacent normal; bp < 0.005 vs. adjacent normal; cp < 0.0005 vs. adjacent normal; dp < 0.05 vs. HP; ep < 0.005 vs. HP; fp < 0.0005 vs. HP; gp < 0.05 vs. TA; hp < 0.005 vs. TA; ip < 0.0005 vs. TA; jp < 0.05 vs. SSA/P; kp < 0.005 vs. SSA/P; lp < 0.0005 vs. SSA/P
NC, adjacent normal colon; HP, hyperplastic polyps; SSA/P, sessile serrated adenoma/polyps; TA, tubular adenoma; SE, standard error; Min, minimum; Max, maximum