Table 4. Univariate and Multivariate logistic regression and ROC curve analysis of mucins and associated O-glycans for colorectal polyps classification.

Univariate Analysis
Marker	Diagnosis		OR (95% CI)		p-value		AUC (95% CI)		Cutpoint		Sensitivity		Specificity
MUC1	SSA/P vs. HP		0.411 (0.156, 1.084)		0.072		0.6772 (0.5531, 0.8012)		<=0.30		0.487		0.848
	SSA/P vs. TA		0.188 (0.069, 0.509)		0.001		0.7639 (0.6545, 0.8733)		<=0.60		0.744		0.722
MUC4	SSA/P vs. HP		0.324 (0.160, 0.657)		0.0018		0.7257 (0.6089, 0.8425)		<=1.2		0.615		0.697
	SSA/P vs. TA		0.745 (0.395, 1.405)		0.36		0.5630 (0.4319, 0.6942)		<=1.2		0.615		0.5
MUC17	SSA/P vs. HP		14.376 (3.664, 56.41)		0.0001		0.7739 (0.6623, 0.8855)		>=0.8		0.667		0.909
	SSA/P vs. TA		5.990 (1.955, 18.346)		0.0017		0.7222 (0.6047, 0.8397)		>=0.80		0.667		0.778
MUC2	SSA/P vs. HP		0.530 (0.210, 1.337)		0.18		0.5960 (0.4640, 0.7279)		<=1.8		0.513		0.727
	SSA/P vs. TA		3.288 (1.573, 6.873)		0.0016		0.6991 (0.5765, 0.8216)		>=1.60		0.718		0.583
MUC5AC	SSA/P vs. HP		9.112 (2.912, 28.51)		0.0001		0.7995 (0.6947, 0.9043)		>=0.9		0.769		0.727
	SSA/P vs. TA		21.755 (5.985, 79.078)		<0.0001		0.9081 (0.8320, 0.9842)		>=0.60		0.923		0.806
Tn/STn-MUC1	SSA/P vs. HP		0.870 (0.317, 2.390)		0.79		0.5085 (0.3756, 0.6415)		<=0.8		0.179		0.939
	SSA/P vs. TA		2.472 (1.016, 6.016)		0.046		0.6353 (0.5095, 0.7611)		>=1.2		0.795		0.444
CA19-9	SSA/P vs. HP		1.279 (0.746, 2.194)		0.37		0.5287 (0.3907, 0.6668)		>2.1		0.333		0.606
	SSA/P vs. TA		54.383 (6.489, 455.7)		0.0002		0.9551 (0.9095, 1.0000)		>=0.80		0.872		1
Multivariate Analysis
Diagnosis		Comparison	AUC	Lower		Upper		Threshold		Sensitivity		Specificity
SSA/P vs. HP		MUC17+MUC5AC	0.865	0.776		0.954		P(SP)>= 0.4928		0.846		0.818
SSA/P vs. TA		MUC1+MUC17+CA19-9	0.9868	0.97		1		P(SPT)>=0.385		0.923		0.972

HP, hyperplastic polyps; SSA/P, sessile serrated adenoma/polyps; TA, tubular adenoma; OR, odds ratio; AUC, area under curve; CI, confidence interval