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. 2016 Oct 11;8(4):7116–7137. doi: 10.18632/oncotarget.12572

Figure 2. Dichotomous impacts of Treg cells on the CNS in neurodegenerative disease.

Figure 2

A. Periphery: Increased Tregs in the periphery in aging may result in a blockade for other immune cell trafficking through the BBB and CP, since weakening or transient depletion of Tregs is able to enhance immune cell trafficking to ameliorate neuro-inflammation in mouse models. B. CNS: Treg cells in the CNS may play a beneficial role, because they are able to suppress active M1 microglia and macrophage, and balance Th17 and γδ17 cells, as well as promote microglia and macrophage to M2 differentiation.