Table 8. . Pharmacokinetic parameters of healthy human volunteers with the test and reference preparation (n = 30).

Pharmacokinetic parameters		Enalapril 20 mg		Enalaprilat
		Reference preparation	Test preparation	Reference preparation	Test preparation
Cmax (ng/ml)	Mean	254.3130 ± 16.1820	249.7880 ± 15.4990	121.3210 ± 10.7660	117.9480 ± 11.5540
tmax (h)	Mean	0.6810 ± 0.2700	0.8060 ± 0.2530	2.2500 ± 0.4870	2.7000 ± 0.5350
AUC 0–72 (ng. h/ml)	Mean	317.4790 ± 16.4780	315.2940 ± 22.3340	1043.1070 ± 50.2960	1052.9040 ± 60.5320
AUC 0-∞ (ng. h/ml)	Mean	319.8340 ± 16.4150	317.7470 ± 22.2500	1086.8190 ± 53.3050	1099.8880 ± 56.1890
kel (h-1)	Mean	0.4970 ± 0.0210	0.4860 ± 0.0200	0.0750 ± 0.0040	0.0730 ± 0.0050
t1/2 (h)	Mean	1.3960 ± 0.0590	1.4290 ± 0.0580	9.2490 ± 0.5320	9.5510 ± 0.6190
Relative bioavailability (%)		100	99.31	100	100.94

C_max: Maximum plasma concentration.

t_max: time require to achieve maximum concentration.

AUC_0–72: area under the plasma concentration time curve from time zero to 72 h.

AUC_0–∞: area under the plasma concentration-time curve from time zero to infinity.

K_el: elimination rate constant.

t_1/2: elimination half life.