. 2016 Oct 13;11(2):164–172. doi: 10.1080/19336918.2016.1247145

Table 1.

GBM-derived EV cargoes and their functional impacts.

	Recipient cells	Cargo	Biological effects
Intra-Tumoral	Tumor cells	mtDNA	nd¹⁸
		miR-1	Tumorgenicity, invasion and growth³⁴
		miR-21	Anti-apoptosis, proliferation^10,17
		hypoxia signatureEGFRvIIIclic1proteinsTrkB	Cell migration¹⁴Tumor growth¹²Tumor growth⁶⁵GBM subtype tumorigenesis²⁵Aggressiveness⁵⁰
	Endothelial cells	miR-9mRNAshypoxia signatureangiogenic factorssemaphorin 3A	Migration, angiogenesis⁶⁶Angiogenesis¹⁰Angiogenesis¹⁴Angiogenesis¹⁰Permeability²¹
	Microglia Monocyte/macrophage	miR-451, miR-21	Cytokine profile³²
Extra-Tumoral	Endothelial cells		Pro-coagulation^{39, 40}
	Endothelial cells Monocyte/macrophage	semaphorin 3A	nd²¹
		TrkB	nd⁵⁰
		proteins	M2 phenotype³⁷
	Lymphocyte	proteins	Immunotolerance⁶⁷

nd: not determined