Table I.

PRDXs are functionally conserved in all three phylogenetic domains.^a

		Identity (%)
Species	Gene symbol	Protein	DNA
H. sapiens PRDX1
vs. P. troglodytes	PRDX1	100.0	99.7
vs. M. mulatta	PRDX1	99.5	98.5
vs. C. lupus	PRDX1	99.0	93.3
vs. B. taurus	PRDX1	96.5	93.6
vs. M. musculus	Prdx1	95.5	90.8
vs. R. norvegicus	Prdx1	97.5	91.3
vs. R. norvegicus	Prdx1l1	97.0	91.3
vs. G. gallus	PRDX1	88.4	78.7
vs. X. tropicalis	LOC101731384	84.9	76.2
vs. X. tropicalis	Prdx1	84.9	76.0
vs. D. rerio	Prdx1	81.3	73.9
H. sapiens PRDX2
vs. P. troglodytes	PRDX2	100.0	99.8
vs. M. mulatta	PRDX2	100.0	98.1
vs. C. lupus	PRDX2	93.4	88.2
vs. B. taurus	PRDX2	91.2	87.4
vs. M. musculus	prdx2	93.4	88.2
vs. R. norvegicus	prdx2	93.4	87.0
vs. X. tropicalis	prdx3	79.6	70.7
vs. X. tropicalis	prdx2	77.5	72.4
vs. D. rerio	prdx2	76.6	72.8
vs. D. melanogaster	Jafrac1	71.3	67.4
vs. A. gambiae	TPX2	68.1	66.0
vs. C. elegans	prdx2	73.2	66.7
vs. S. cerevisiae	TSA1	66.8	61.1
vs. S. pombe	tpx1	68.8	60.8
vs. A. thaliana	2Cys Prx B	63.8	61.2
vs. A. thaliana	AT3G11630	64.4	61.3
vs. O. sativa	Os02g0537700	62.2	61.5
H. sapiens PRDX3
vs. P. troglodytes	PRDX3	100.0	99.6
vs. M. mulatta	PRDX3	97.7	97.5
vs. C. lupus	PRDX3	91.4	88.2
vs. B. taurus	PRDX3	89.1	88.8
vs. M. musculus	Prdx3	86.3	84.2
vs. R. norvegicus	Prdx3	85.2	83.2
vs. G. gallus	PRDX3	79.2	71.7
vs. M. mulatta	LOC719764	99.2	97.8
vs. D. rerio	prdx3	75.4	66.8
vs. D. melanogaster	Prx3	64.5	61.7
vs. A. gambiae	TPX1	63.9	58.6
vs. C. elegans	prdx3	66.8	60.4
vs. S. cerevisiae	TSA2	57.3	57.1
vs. K. lactis	KLLA0B01628g	56.8	58.7
vs. E. gossypii	AGOS_AER312W	57.8	59.5
H. sapiens PRDX4
vs. M. mulatta	PRDX4	98.5	98.4
vs. C. lupus	PRDX4	93.0	89.2
vs. B. taurus	PRDX4	93.8	90.8
vs. M. musculus	Prdx4	95.0	89.1
vs. R. norvegicus	Prdx4	94.5	90.3
vs. G. gallus	PRDX4	91.9	81.6
vs. X. tropicalis	prdx4	93.6	81.1
vs. D. rerio	prdx4	88.7	74.8
vs. D. melanogaster	Jafrac2	71.0	64.4
vs. A. gambiae	TPX3	74.7	65.9
H. sapiens PRDX5
vs. P. troglodytes	PRDX5	99.5	99.7
vs. B. taurus	PRDX6	95.1	92.9
vs. C. lupus	PRDX5	85.5	84.9
vs. B. taurus	PRDX5	81.9	83.8
vs. M. musculus	Prdx5	87.2	86.1
vs. R. norvegicus	Prdx5	88.1	85.3
vs. X. tropicalis	prdx5	67.3	65.2
vs. D. rerio	prdx5	61.3	64.0
vs. D. melanogaster	Prdx5	59.5	62.4
vs. A. gambiae	AgaP_AGAP	60.0	60.9
	001325
vs. K. lactis	KLLA0A07271g	39.3	46.8
vs. E. gossypii	AGOS_ADL154C	40.5	48.4
vs. S. pombe	SPCC330.06c	35.3	42.7
vs. M. oryzae	MGG_00860	44.4	53.0
vs. N. crassa	NCU06880	44.1	52.8
vs. A. thaliana	AT1G60740	42.7	49.7
vs. A. thaliana	TPX1	43.9	50.5
vs. A. thaliana	TPX2	42.7	49.7
vs. O. sativa	Os01g0675100	44.0	49.9
H. sapiens PRDX6
vs. P. troglodytes	PRDX6	100.0	99.7
vs. M. mulatta	PRDX6	98.7	98.4
vs. C. lupus	PRDX6	92.9	91.5
vs. M. musculus	Prdx6	89.7	87.4
vs. R. norvegicus	Prdx6	91.5	88.8
vs. G. gallus	PRDX6	86.4	78.0
vs. X. tropicalis	prdx6	76.9	71.0
vs. D. rerio	prdx6	73.6	67.3
vs. D. melanogaster	Prx6005	61.0	58.9
vs. A. gambiae	TPX5	60.2	59.7
vs. C. elegans	prdx6	52.4	55.6
vs. S. cerevisiae	PRX1	51.0	54.8
vs. K. lactis	KLLA0E20285g	48.6	54.6
vs. E. gossypii	AGOS_AGR368W	50.5	55.4
vs. M. oryzae	MGG_08256	53.5	58.1
vs. N. crassa	NCU06031	53.3	58.7
vs. A. thaliana	PER1	52.6	55.8
vs. O. sativa	Os07g0638300	53.5	59.3
vs. O. sativa	Os07g0638400	53.9	56.5

^aHomologs of the PRDX genes are listed in the Table. In the figure the Pairwise Alignment Scores and evolutionary distances have been reported (http://www.ncbi.nlm.nih.gov/gene/). PRDX, peroxiredoxin; TPX, thiol peroxidase.