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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Crit Care Clin. 2017 Apr;33(2):245–258. doi: 10.1016/j.ccc.2016.12.001

Figure 3. MDSCs in PICS.

Figure 3

Characterization of MDSCs (CD33+CD11b+HLA−DR−/low) in 72 trauma and surgical ICU patients with severe sepsis/septic shock51. A) After sepsis onset, circulating MDSCs expand early and are persistently elevated by a significant margin over the first 28 days when compared to healthy controls. B & C) The commonly observed high ratio of monocytic/granulocytic MDSCs seen in healthy subjects is reversed in patients with severe sepsis/septic shock.

From Mathias B, Delmas AL, Ozrazgat-Baslanti T, et al. Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock. Annals of surgery. May 9 2016

*p<0.05 when compared to HC subjects

# p<0.05 when compared to SS/SS patients at 12 hours.