Table 1. Harmonizing measures from the CARRS and MASALA studies.
Measure | Methodology in CARRS | Methodology in MASALA | Harmonized measure |
---|---|---|---|
Income | Monthly household income (categories) | Annual household income (categories) | Compare individuals in top tertile of income versus not |
Physical activity | International Physical Activity Questionnaire (IPAQ)[37] | Typical Week’s Physical Activity Questionnaire[38] | Weekly vigorous physical activity (yes/no), since both surveys described vigorous physical activity similarly |
Diet | Frequency of consumption of major food groups for the past year (including typical foods consumed in India) | Study of Health Assessment and Risk in Ethnic Groups (SHARE) questionnaire[39] | Fruit and vegetable intake (number of times/day), since both surveys described these food groups similarly |
Blood pressure | After 5 minutes of rest, Seated blood pressure at rest at least two times, using an oscillometric device (Omron Dailan Co., Ltd, Dalian, Liaoning, China). A third measurement was obtained if the difference between the first two systolic or diastolic measurements was more than 10 mmHg and 5 mmHg, with at least 30 seconds in between each. | After 5 minutes of rest, seated blood pressure at rest three times with at one minute in between each reading, using an oscillometric device (V100 Vital Signs Monitor, GE Healthcare, Fairfield, CT. U.S.) | Average of last two readings |
Medications | Obtained 1 year after baseline; individual medication names | Obtained at baseline; individual medication names | Categorized by study investigators into broader categories (yes/no): 1.Blood pressure medications, 2. ACEI/ARB therapy, 3. Anti-glycemic therapy, including insulin, and 4. Lipid therapy, including statins, fibrates and ezetimibe |
Chronic kidney disease | Spot urine albumin measured via immunoturbidimetric assaySerum and urine creatinine measured via rate-blanked compensated kinetic Jaffe method | Spot urine albumin measured via immunoturbidimetric assay | Creatinine assays in both laboratories traceable to IDMS. CKD defined in both studies as: 1. Single urine albumin to creatinine ratio ≥ 3.4 mg/mmol [30 mg/g], or 2. Single calculation of CKD-EPI eGFR < 60 ml/min/1.73m2 |
Serum and urine creatinine measured via enzymatic colorometric method |
Abbreviations: IDMS- isotope dilution mass spectrometry; CKD-chronic kidney disease; eGFR-estimated glomerular filtration rate.