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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: DNA Repair (Amst). 2016 Mar 2;40:67–76. doi: 10.1016/j.dnarep.2016.02.002

Fig. 6. RNF8 and HERC2 work together to maintain replication fork progression on UV damaged DNA.

Fig. 6

(A-C) Replication stalling in response to 20 J/m2 UV (red bars) or sham irradiation (blue bars) in WT (A), HERC2-/-(B) and RNF8-/- (C) cell lines. Each data set is derived from measurement of at least 100 forks. (D) The data for cells carrying the indicated genotypes was plotted as a cumulative percentage (y-axis) of forks at each ratio (x-axis). The P-values of the Kolmogorov–Smirnov test for ratio distribution of each mutant for UV compared to sham treatment are *p<0.002 and **p<0.001.