Figure 1.

Overproduced Ccr4 or Cln3 suppresses aneuploidy triggered by loss of Ulp2. Loss of Ulp2 (top right) leads to accumulation of polySUMO-conjugated substrates, duplication of Chromosome I (ChrI) and XII, and reduced cell fitness (irregular cell outline). Increased dosage of CCR4 (bottom left) suppresses the aneuploidy and growth defects and partially reduces the aberrantly high SUMO-conjugate levels of ulp2Δ cells (Ref.⁴ and unpublished data). Overexpressing CLN3 (bottom right) suppresses the ChrI, but not ChrXII, disomy, likely through (partial) normalization of cell-cycle progression.