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. 2016 Dec 22;26(1):210–225. doi: 10.1093/hmg/ddw373

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Increased polygenic burden for schizophrenia is associated with altered DNA methylation. (A) Schizophrenia samples included in our study scored significantly higher on a polygenic risk score derived from a recent large collaborative GWAS of schizophrenia. (B) The top-ranked PRS-associated DMP was cg20640266 (annotated to ZNF618) in the cerebellum. (C) The top-ranked multi-region PRS-associated DMP was cg04910228 (annotated to the TSNAX-DISC1 locus).