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. 2017 Mar 15;12(3):e0172632. doi: 10.1371/journal.pone.0172632

Fig 2. Englerin A induces ER stress signaling and morphological changes in the ER.

Fig 2

Western blot analysis (A) was performed using protein extracts obtained from A498 cells treated with 0.1% DMSO (vehicle) or 100 nM englerin A for the indicated times. ER morphology (B) was imaged by fluorescence confocal microscopy of UO-31 cells that were treated with vehicle or 25 nM englerin A for 28.5h followed by staining of cells with ER-ID® Green and Hoechst stain. Arrows show areas of the ER with disrupted fine tubular network.