Table 2. Percentages (95% CIs) of subjects with abnormal spatial point pattern analysis parameters >97.5th percentile and abnormal CEAI and CNFL *<2.5th percentile of the control group.
| Control (n = 47) | Diabetes (n = 86) | P value | |
|---|---|---|---|
| ESD (%) | 8.5 (3.0–18.4) | 18.6 (12.0–26.9) | 0.136 |
| MINN (%) | 2.1 (0.1–9.7) | 19.3 (12.5–27.8)† | 0.005 |
| MINNSD (%) | 4.3 (0.8–12.8) | 21.7 (14.5–30.4)† | 0.01 |
| MENN (%) | 4.3 (0.8–12.8) | 8.4 (4.0–15.3)† | 0.487 |
| MENNSD (%) | 6.4 (1.8–15.7) | 12.0 (6.7–19.6)† | 0.374 |
| VCA (%) | 4.3 (0.8–12.8) | 14.5 (8.6–22.4)† | 0.084 |
| VCASD (%) | 6.4 (1.8–15.7) | 21.7 (14.5–30.4)† | 0.026 |
| CEAI (%)* | 4.3 (0.8–12.8) | 11.9 (6.6–19.4)‡ | 0.210 |
| MADL (%) | 4.3 (0.8–12.8) | 23.5 (16.2–32.3)§ | 0.003 |
| MADPC (%) | 4.3 (0.8–12.8) | 16.5 (10.2–24.5)§ | 0.051 |
| CNFL (%)*|| | 4.3 (0.8–12.8) | 18.6 (12.0–26.9) | 0.019 |
||Previously published in ref. [14];
missing values:
§n = 1;
‡n = 2;
†n = 3.
MINN: minimum nearest neighbor distances between branching points, MENN: mean nearest neighbor distances between branching points, MINNSD: standard deviation of minimum nearest neighbor distances between branching points, MENNSD: standard deviation of mean nearest neighbor distances between branching points, CEAI: Clark and Evans aggregation index, ESD: mean empty space distance for a branching point pattern, VCA: Voronoi cell area, VCASD: standard deviation of Voronoi cell area, MADL: maximum absolute deviation from complete spatial randomness based on L-functions, MADPC: maximum absolute deviation from complete spatial randomness based on pair-correlation functions, CSR: complete spatial randomness, CNFL: corneal nerve fiber length