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editorial
. 2016 Dec 12;8(1):1–2. doi: 10.18632/oncotarget.13926

Figure 1. RIPK1 a master regulator of cell death and inflammation.

Figure 1

A. Schematic representation of the versatile functions of RIPK1. Basically, RIPK1 regulates pro-survival and inflammatory signaling in addition to apoptotic and necroptotic cell death through its different regulatory domains viz. adaptor, kinase and RHIM docking fnnction. B. Schematic representation of how the RHIM domain of RIPK1 acts as an essential break on constitutive ZBP1 activation. RIPK1 with an inactivating mutation in the RHIM that abolishes the capacity of RIPK1 to interact with other cellular RHIM containing proteins induces ZBP11RIPK3/MLKL- mediated necroptosis and inflammation. This defect signaling results in a spontaneous phenotype in the mentioned RIPK1 transgenic mice, which are briefly described. IFN, interferon; RIPK, receptor interacting protein kinase; RIPK1 mRHIM, mice expressing RIPK1 with an inactivating mutation in the RHIM; RIPK1 mRHIMtE-Ko, mice with skin specific expression of RIPK1 with an inactivating mutation in the RHIM; RIPK1 E-Ko, mice with skin specific deletion ofRIPK1; RHIM, RIP homotypic interaction motif; ZBP1, Z-DNA binding protein 1.