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. 2016 Nov 24;8(1):1007–1022. doi: 10.18632/oncotarget.13537

Figure 4. Benztropine mesylate treatment improves the efficiency of chemotherapy in vitro.

Figure 4

A. Schematic representation of the experimental approach taken to quantify the mammosphere formation efficiency of 4T1-luc2 and MDA-MB-231 cells by combination treatment with benztropine mesylate (5 μM) and paclitaxel (10 nM) or as single agent treatment. B. Representative images and quantification of mammosphere numbers after 6 days. C. Schematic representation of the experimental approach taken to quantify the mammosphere formation efficiency of pretreated-4T1-luc2 cells and MDA-MB-231 cells by combination treatment with benztropine mesylate and paclitaxel or by single agent treatment. D. Representative images and quantification of mammosphere numbers after 6 days. Data are expressed as mean±SD (n=6). ***p<0.001 compared with DMSO control (one-way ANOVA); #p<0.05 compared with benztropine mesylate group.