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. 2016 Nov 26;8(1):1555–1568. doi: 10.18632/oncotarget.13657

Figure 2. Afatinib shows cytotoxic effect on NB cells.

Figure 2

A. Six NB cell lines (IMR-32, NGP, NB-19, SK-N-AS, SH-SY5Y and LA-N-6) were treated with increasing concentrations of afatinib for 72 hrs. Cell viability was then assessed by a CCK-8 assay. Data were presented as mean ± SD. P <0.01 (**), or P <0.001 (***) (Student's t-test) were indicated. B. The IC50 values of afatinib on the tested NB cell lines and EGFR status of each cell line were listed. Five of the six NB cell lines were EGFR wild-type (WT). C. Morphologic changes of the six NB cell lines treated with afatinib for 72 hrs were shown.