Table 4. The diagnostic performance for US features, CSE, ARFI elastography and combined ARFI elastography.
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | Az (95 % CIs) | ||
|---|---|---|---|---|---|---|---|
| US feature | |||||||
| Moderate hypoechogenicity | 47.4% (18/38) | 49.2% (32/65) | 35.3% (18/51) | 61.5% (32/52) | 48.5% (50/103) | 0.483 (0.367-0.599) | |
| Marked hypoechogenicity | 50% (19/38) | 93.8% (61/65) | 82.6% (19/23) | 76.3% (61/80) | 77.7% (80/103) | 0.719 (0.622-0.803) | |
| Irregular shape | 89.5% (34/38) | 33.8% (22/65) | 44.2% (34/77) | 84.6% (22/26) | 54.4% (56/103) | 0.617 (0.516-0.711) | |
| Poorly defined margin | 89.5% (34/38) | 35.4% (23/65) | 44.7% (34/76) | 85.2% (23/27) | 55.3% 57/103 | 0.624 (0.523-0.718) | |
| Absence of halo sign | 84.2% (32/38) | 36.9% (24/65) | 43.8% (32/73) | 80% (24/30) | 54.4% (56/103) | 0.606 (0.505-0.701) | |
| Microcalcification | 63.2% (24/38) | 78.5% (51/65) | 63.2% (24/38) | 78.5% (51/65) | 72.8% (75/103) | 0.708 (0.610-0.794) | |
| Height/width≥1 | 65.8% (25/38) | 83.1% (54/65) | 69.4% (25/36) | 80.6 (54/67) | 76.5 (79/103) | 0.744 (0.649-0.825) | |
| CSE | |||||||
| CSE score≥3 | 84.2% (32/38) | 47.7% (31/65) | 48.5% (32/66) | 83.8% (31/37) | 61.2% (63/103) | 0.660 (0.560-0.750) | |
| ARFI elastography | |||||||
| ARFI imaging grade≥4 | 92.1% (35/38) | 80.0% (52/65) | 72.9% (35/48) | 94.5% (52/55) | 84.5% (87/103) | 0.861 (0.748-0.900) | |
| SWS>2.94 m/s | 52.6% (20/38) | 92.3% (60/65) | 80% (20/25) | 76.9% (60/78) | 77.7% (80/103) | 0.725 (0.628-0.808) | |
| SWS ratio>1.09 | 76.3% (29/38) | 70.8% (46/65) | 60.4% (29/48) | 83.6% (46/55) | 72.8% (75/103) | 0.735 (0.639-0.817) | |
| Combined ARFI | |||||||
| b+c | 52.6% (20/38) | 95.4% (62/65) | 87.0% (20/23) | 77.5% (62/80) | 79.6% (82/103) | 0.740 (0.644-0.822) | |
| a+b | 47.4% (18/38) | 100% (65/65) | 100% (18/18) | 76.5% (65/85) | 80.6% (83/103) | 0.737 (0.641-0.819) | |
| a+c | 68.4% (26/38) | 96.9% (63/65) | 92.9% (26/28) | 84% (63/75) | 86.4% (89/103) | 0.827 (0.740-0.894) | |
| b/c | 76.3% (29/38) | 67.7% (44/65) | 58% (29/50) | 83.0% (44/53) | 70.9% (73/103) | 0.720 (0.623-0.804) | |
| a+ b/c | 76.3% (29/38) | 100% (65/65) | 100% (29/29) | 87.8% (65/74) | 91.3% (94/103) | 0.882 (0.803-0.937) |
PPV positive predictive value; NPV negative predictive value; Az Area under the curve; CIs confidence intervals
a: ARFI imaging grade≥4 ; b: SWS>2.94 m/s; c: SWS ratio>1.09