Table 2. Comparison of patients by Metavir score.
Characteristics | Testing Set (n= 108) | Validation Set (n= 324) | ||||
---|---|---|---|---|---|---|
Non-cirrhosis (n= 73) | Cirrhosis (n= 35) | P | Non-cirrhosis (n= 192) | Cirrhosis (n = 132) | P | |
Age | 50±11.75 | 54±11 | 0.121 | 52±12 | 54±11 | 0.163 |
Gender (male v female) | 60 v 13 | 25 v 10 | 0.785 | 162 v 30 | 114 v 18 | 0.621 |
ALT (U/L) | 46.93±39.66 | 56.06±49.39 | 0.344 | 58.66±91.54 | 62.06±103.14 | 0.012 |
AST (U/L) | 42.79±25.24 | 62.77±36.78 | <0.001 | 46.61±60.35 | 46.83±38.06 | 0.002 |
TB (mg/dL) | 0.95±0.59 | 1.19±0.62 | 0.009 | 0.88±0.66 | 1.00±0.65 | 0.039 |
ALB (g/L) | 41.51±6.84 | 39.37±5.99 | 0.102 | 44.39±4.61 | 42.29±4.50 | <0.001 |
Creatinine (mg/dL) | 0.74±0.17 | 0.86±0.21 | 0.004 | 0.90±0.55 | 0.94±0.47 | 0.452 |
AFP (ng/ml) (≤20 v >20) | 31 v 42 | 17 v 18 | 0.552 | 70 v 122 | 56 v 76 | 0.280 |
HBV DNA level (≤105 v >105copies/ml) | 34 v 39 | 15 v 20 | 0.837 | 79 v 113 | 50 v 82 | 0.566 |
INR | 1.04±0.013 | 1.13±0.016 | 0.005 | 1.00±0.07 | 1.05±0.09 | <0.001 |
Platelet count (109/L) | 156.22±61.69 | 106.66±63.70 | 0.001 | 157.59±58.77 | 124.89±64.82 | <0.001 |
Tumor number (single v multiple) | 55 v 18 | 30 v 5 | 0.220 | 172 v 20 | 111 v 21 | 0.145 |
Vascular invasion (yes v no) | 28 v 45 | 20 v 15 | 0.067 | 54 v 138 | 30 v 102 | 0.277 |
Tumor encapsulation (yes v no) | 17 v 56 | 5 v 30 | 0.279 | 108 v 84 | 68 v 64 | 0.401 |
Tumor size (≤5.0 v >5.0) | 35 v 38 | 13 v 22 | 0.293 | 123 v 69 | 100 v 32 | 0.028 |
TNM stage (I-II v III A) | 39 v 34 | 16 v 19 | 0.455 | 155 v 37 | 122 v 10 | 0.785 |
Postoperative TACE (yes v no) | 30 v 43 | 15 v 20 | 0.621 | 62 v 130 | 54 v 78 | 0.767 |
Re-operation (yes v no) | 6 v 67 | 5 v 30 | 0.469 | 16 v 176 | 12 v 120 | 0.812 |
Abbreviations: HBV: hepatitis B virus; HCC: hepatocellular carcinoma; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TB: total bilirubin; ALB: Albumin; INR: international normal ratio; AFP: alpha fetoprotein; TACE: transarterial chemoembolization.