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. 2016 Sep 20;8(1):1774–1787. doi: 10.18632/oncotarget.12152

Table 2. Comparison of patients by Metavir score.

Characteristics Testing Set (n= 108) Validation Set (n= 324)
Non-cirrhosis (n= 73) Cirrhosis (n= 35) P Non-cirrhosis (n= 192) Cirrhosis (n = 132) P
Age 50±11.75 54±11 0.121 52±12 54±11 0.163
Gender (male v female) 60 v 13 25 v 10 0.785 162 v 30 114 v 18 0.621
ALT (U/L) 46.93±39.66 56.06±49.39 0.344 58.66±91.54 62.06±103.14 0.012
AST (U/L) 42.79±25.24 62.77±36.78 <0.001 46.61±60.35 46.83±38.06 0.002
TB (mg/dL) 0.95±0.59 1.19±0.62 0.009 0.88±0.66 1.00±0.65 0.039
ALB (g/L) 41.51±6.84 39.37±5.99 0.102 44.39±4.61 42.29±4.50 <0.001
Creatinine (mg/dL) 0.74±0.17 0.86±0.21 0.004 0.90±0.55 0.94±0.47 0.452
AFP (ng/ml) (≤20 v >20) 31 v 42 17 v 18 0.552 70 v 122 56 v 76 0.280
HBV DNA level (≤105 v >105copies/ml) 34 v 39 15 v 20 0.837 79 v 113 50 v 82 0.566
INR 1.04±0.013 1.13±0.016 0.005 1.00±0.07 1.05±0.09 <0.001
Platelet count (109/L) 156.22±61.69 106.66±63.70 0.001 157.59±58.77 124.89±64.82 <0.001
Tumor number (single v multiple) 55 v 18 30 v 5 0.220 172 v 20 111 v 21 0.145
Vascular invasion (yes v no) 28 v 45 20 v 15 0.067 54 v 138 30 v 102 0.277
Tumor encapsulation (yes v no) 17 v 56 5 v 30 0.279 108 v 84 68 v 64 0.401
Tumor size (≤5.0 v >5.0) 35 v 38 13 v 22 0.293 123 v 69 100 v 32 0.028
TNM stage (I-II v III A) 39 v 34 16 v 19 0.455 155 v 37 122 v 10 0.785
Postoperative TACE (yes v no) 30 v 43 15 v 20 0.621 62 v 130 54 v 78 0.767
Re-operation (yes v no) 6 v 67 5 v 30 0.469 16 v 176 12 v 120 0.812

Abbreviations: HBV: hepatitis B virus; HCC: hepatocellular carcinoma; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TB: total bilirubin; ALB: Albumin; INR: international normal ratio; AFP: alpha fetoprotein; TACE: transarterial chemoembolization.